azaperone

Azaperone is a pyridinylpiperazine and butyrophenone neuroleptic drug with sedative, tranquilizing, and antiemetic effects. It is primarily used as a veterinary tranquilizer, especially in pigs and occasionally in elephants. Its use in humans as an antipsychotic is rare. Azaperone acts mainly as a dopamine receptor antagonist (notably at the D3 dopamine receptor), but also exhibits antihistaminic, anticholinergic, and alpha-adrenergic blocking properties. The drug produces sedation by inhibiting central dopaminergic pathways and may cause hypotension due to its peripheral vasodilatory effects[1][2][5]. It is administered intramuscularly, metabolized hepatically, and has an elimination half-life of about 4 hours[2].

Brand names

StresnilSuicalm

Other names

Azaperon