Drug intelligence / Profile preview

azatadine + prednisone + pseudoephedrine + sulfamethoxazole + trimethoprim

Development stage
Unknown
Lead developer
Merck
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Oral, Intravenous
01

Overview

This is a combination drug containing five active pharmaceutical ingredients: - **Azatadine** is an H1 antihistamine that acts as a histamine H1 receptor antagonist, used to treat allergic rhinitis and related symptoms by blocking the effects of histamine in the body[5]. - **Prednisone** is a synthetic glucocorticoid corticosteroid with potent anti-inflammatory and immunosuppressive properties, commonly used for various inflammatory and autoimmune conditions[8]. - **Pseudoephedrine** is a sympathomimetic decongestant that acts primarily as an agonist at alpha adrenergic receptors, leading to vasoconstriction and relief of nasal congestion[4][7]. - **Sulfamethoxazole** is a sulfonamide antibiotic that inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA). - **Trimethoprim** is an antibiotic that inhibits bacterial dihydrofolate reductase, thereby blocking folic acid synthesis. Sulfamethoxazole and trimethoprim are often combined for synergistic antibacterial activity against susceptible organisms. This specific five-drug combination does not correspond to any known marketed product or standard therapy. Each component has distinct mechanisms targeting allergy symptoms (azatadine), inflammation (prednisone), nasal congestion (pseudoephedrine), and bacterial infections (sulfamethoxazole/trimethoprim).

02

Targets

M1 (Muscarinic acetylcholine receptor M1)NET (Norepinephrine Transporter)DHFR (Dihydrofolate reductase)AR (Adrenergic receptors)HRH1 (Histamine H1 Receptor)GR (Glucocorticoid receptor)DHPS (Dihydropteroate synthase)

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