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azd-9164
- Development stage
- Discontinued
- Lead developer
- AstraZeneca
- Modality
- Small Molecules
- Administration
- Inhalation
01
Overview
AZD-9164 is a small molecule drug developed as an inhaled long-acting muscarinic antagonist (LAMA) bronchodilator for the treatment of chronic obstructive pulmonary disease (COPD). It acts primarily as a potent antagonist of the muscarinic acetylcholine receptor M3 (M3 receptor), thereby inhibiting parasympathetic bronchoconstriction and promoting bronchodilation. Preclinical studies demonstrated that AZD-9164 had a longer duration of action than ipratropium in animal models and showed an improved therapeutic index for lung versus systemic effects. Clinical trials reached up to Phase II; however, development was discontinued after observations of transient paradoxical bronchospasm in COPD patients following inhalation[1][2][3][6][7].
- Other names
- 977LWC4O5DJ3.232.015EJ-3.232.015EJ 3.232.015E1034978-04-5
02
Targets
CHRM3 (M3)
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