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AZD2389 + quinidine

Development stage: Unknown
Lead developer: AstraZeneca
Modality: Small Molecules
Administration: Oral

Overview

AZD2389 + quinidine is an investigational combination of AZD2389, a novel small molecule, co-administered with quinidine, a known antiarrhythmic agent. The combination is under clinical study to assess the pharmacokinetics and safety of AZD2389 when given with quinidine in healthy participants. Quinidine is likely included to evaluate drug-drug interaction effects on the metabolism of AZD2389. AZD2389 is being developed by AstraZeneca, primarily for liver diseases such as advanced chronic liver disease and liver fibrosis. The precise mechanism of action of AZD2389 is not specified in current trial data, but participants with history of hypersensitivity to dipeptidyl peptidase 4 (DPP4) inhibitors are excluded, suggesting AZD2389 may involve DPP4 modulation[1][3][7].

Other names: azd2389 + quinidine

Targets

FAP (Fibroblast activation protein alpha)

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