AZD3480 + donepezil

**AZD3480 + donepezil** is a combination of two drugs: AZD3480, a selective agonist of central neuronal nicotinic acetylcholine receptors (primarily α4β2 and α2β2), and donepezil, a reversible acetylcholinesterase inhibitor. AZD3480 acts to stimulate neuronal nicotinic cholinergic receptors, potentially enhancing cognitive function, while donepezil inhibits acetylcholinesterase, thereby increasing synaptic acetylcholine and improving cognitive and behavioral symptoms of Alzheimer's disease. The combination has primarily been investigated in early-stage research and pharmacokinetic studies aiming to assess potential cognitive benefits and drug-drug interactions in the context of Alzheimer's disease and related dementias[1][2][4][5].