AZD7545

**AZD7545** is a synthetic small molecule belonging to the benzamide class. It was developed as an experimental compound and is not approved for clinical use. The primary mechanism of action is as an inhibitor of pyruvate dehydrogenase kinase (PDK), specifically targeting PDK isoforms involved in the regulation of glucose metabolism. By inhibiting PDK activity, AZD7545 promotes activation of the pyruvate dehydrogenase complex (PDC), thereby enhancing mitochondrial oxidation of pyruvate and shifting cellular metabolism from glycolysis toward oxidative phosphorylation. This mechanism has been explored for potential applications in metabolic diseases and cancer therapy due to its effects on cellular energy metabolism[1][3].

Other names

4-[(3-chloro-4-{[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl]amino}phenyl)sulfonyl]-N,N-dimethylbenzamide4-{3-chloro-4-[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamido]benzenesulfonyl}-N,N-dimethylbenzamide(R)-4-(3-chloro-4-(3,3,3-trifluoro-2-hydroxy-2-methylpropanamido)phenylsulfonyl)-N,N-dimethylbenzamide