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AZD7594 + abediterol
- Development stage
- Unknown
- Lead developer
- AstraZeneca
- Modality
- Small Molecules
- Administration
- Inhalation
01
Overview
AZD7594 + abediterol is an inhaled fixed-dose combination (FDC) therapy being developed by AstraZeneca for the treatment of chronic obstructive pulmonary disease (COPD) and asthma. The combination consists of AZD7594 (also known as velsecorat), a non-steroidal, potent, and selective modulator of the glucocorticoid receptor (SGRM), and abediterol, a novel long-acting beta-2 adrenergic receptor agonist (LABA). AZD7594 is designed to provide anti-inflammatory effects with a potentially reduced systemic side-effect profile compared to traditional inhaled corticosteroids, while abediterol provides sustained bronchodilation. The combination is intended for once-daily administration via a dry powder inhaler (DPI) to improve lung function and manage symptoms in patients with obstructive airway diseases.
- Other names
- AZD7594/abediterolvelsecorat + abediterolvelsecoratabediterol
02
Targets
GR (Glucocorticoid receptor)ADRB2 (β2)
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