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AZD7762 + irinotecan
- Development stage
- Discontinued
- Lead developer
- AstraZeneca
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
AZD7762 + irinotecan is a combination of a **selective checkpoint kinase inhibitor** (AZD7762) and a **topoisomerase I inhibitor** (irinotecan) developed for the treatment of advanced solid tumors. **AZD7762** is a potent, selective ATP-competitive inhibitor of Chk1 (checkpoint kinase 1), which disrupts cell cycle arrest in response to DNA damage, thereby potentiating the cytotoxicity of DNA-damaging agents. Irinotecan inhibits topoisomerase I, preventing DNA re-ligation and causing cell death. Preclinical studies have shown that AZD7762 enhances the effect of irinotecan and its active metabolite SN-38. This combination was investigated in a Phase I open-label, dose-escalation clinical trial in patients with advanced solid malignancies, administered via intravenous infusion. The trial was sponsored and developed by AstraZeneca.
- Brand names
- Campto
- Other names
- irinotecan hydrochloride
02
Targets
CHEK1 (Checkpoint kinase 1)CHEK2 (Checkpoint kinase 2)FXR (Farnesoid x-activated receptor)TOP1 (DNA Topoisomerase I)
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