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AZD7986 + itraconazole

Development stage: Unknown
Lead developer: AstraZeneca
Modality: Small Molecules
Administration: Oral

Overview

AZD7986 + itraconazole refers to the combination of AZD7986, a small molecule inhibitor of dipeptidyl peptidase 1 (DPP1), and itraconazole, a triazole antifungal agent. AZD7986 blocks DPP1, an enzyme essential for activation of neutrophil serine proteases such as neutrophil elastase, aiming for disease modification in neutrophil-driven inflammatory conditions like COPD and related lung diseases. Itraconazole inhibits fungal cytochrome P450-dependent 14α-demethylase, preventing ergosterol synthesis and fungal cell membrane formation. The combination was primarily studied to assess pharmacokinetic interactions; itraconazole is a strong CYP3A4 inhibitor and may impact the metabolism and exposure of AZD7986.

Brand names: Sporanox
Other names: dipeptidyl peptidase 1 inhibitor + itraconazoleAZD7986 + SporanoxAZD7986 + itraconazole oral solution

Targets

CYP3A4 (Cytochrome P450 3A4)CTSC (DPP1)CYP51A1 (Sterol 14α-demethylase)

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