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AZD9056 + simvastatin
- Development stage
- Unknown
- Lead developer
- AstraZeneca
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
AZD9056 + simvastatin is a combination of two pharmaceutical agents studied together primarily to assess pharmacokinetic interactions. AZD9056 is an oral small molecule antagonist of the P2X7 receptor, developed by AstraZeneca for potential use in inflammatory diseases such as osteoarthritis and rheumatoid arthritis. Simvastatin is an HMG-CoA reductase inhibitor (statin) used to lower LDL cholesterol and reduce cardiovascular risk; it acts by inhibiting the enzyme responsible for cholesterol biosynthesis in the liver. The combination has been evaluated in healthy volunteers to determine if co-administration alters the pharmacokinetics or safety profile of either drug[2][4][5].
- Other names
- AZD9056 + simvastatin
02
Targets
HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)P2RX7 (P2X purinoceptor 7)
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