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Drug intelligence / Profile preview
azintuxizumab vedotin
- Development stage
- Discontinued
- Lead developer
- AbbVie
- Modality
- Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics, Recombinant Proteins and Enzymes
- Administration
- Intravenous
01
Overview
Azintuxizumab vedotin is an investigational antibody-drug conjugate (ADC) developed by AbbVie for the treatment of multiple myeloma. It consists of a humanized and chimeric monoclonal IgG1-kappa antibody targeting SLAMF7 (also known as CS1, CD319), a cell-surface glycoprotein highly expressed on multiple myeloma cells, conjugated to the cytotoxic agent monomethyl auristatin E (MMAE) via a cathepsin B-cleavable peptide linker. The mechanism of action involves binding to SLAMF7 on malignant plasma cells, internalization of the ADC, and subsequent release of MMAE inside the cell, leading to microtubule disruption and apoptosis. Azintuxizumab vedotin has been studied in clinical trials for relapsed or refractory multiple myeloma but has not received regulatory approval[1][2][3][4][5][6][7].
- Other names
- azintuxizumab vedotinABBV-838ABBV838ABBV 838
02
Targets
SLAMF7 (Signaling lymphocytic activation molecule family member 7)
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