azlocillin

Azlocillin is a semisynthetic, extended-spectrum acylampicillin antibiotic belonging to the ureidopenicillin subclass of beta-lactam antibiotics. It acts by binding to penicillin-binding proteins (PBPs) within the bacterial cell wall, thereby inhibiting the final stage of peptidoglycan cross-linking essential for bacterial cell wall synthesis. This leads to cell lysis mediated by autolytic enzymes such as autolysins and may also involve disruption of an autolysin inhibitor[1][2][5][7][8]. Azlocillin exhibits broad-spectrum antibacterial activity against both gram-negative and gram-positive organisms, including *Pseudomonas aeruginosa*, *Escherichia coli*, *Haemophilus influenzae*, *Streptococcus* spp., *Enterococcus* spp., *Listeria monocytogenes*, *Proteus mirabilis*, *Salmonella* spp., and *Shigella* spp.[2][5][8]. It was primarily used for severe infections caused by susceptible bacteria but is no longer marketed in some regions[5].

Brand names

Azlin

Other names

azlocillin sodiumazlocillin sodium salt