azosemide

Azosemide is a small molecule loop diuretic of the monosulfamyl class, used primarily to treat hypertension, edema (including cardiac and renal edema), ascites, and fluid overload conditions such as those associated with congestive heart failure, liver disease, and nephrotic syndrome. It acts mainly by inhibiting sodium and chloride reabsorption in both the medullary and cortical segments of the thick ascending limb of the loop of Henle in the kidney. This results in increased excretion of water, sodium, chloride, and other electrolytes. The exact molecular mechanism is not fully understood but is similar to that of furosemide; however, intravenous azosemide has a significantly greater diuretic effect than furosemide due to less first-pass metabolism. Oral bioavailability is low (~20%), with peak plasma concentrations reached within 3–4 hours after administration. The drug exhibits high protein binding (>95%) and has a terminal half-life of about 2–3 hours[1][2][5][6][7][9].

Brand names

DiartAZOSEMIDE Tablets 60mg "DSEP"

Other names

AzosemidAzosemida27589-33-9