Drug intelligence / Profile preview

Azoxystrobin

Development stage
Unknown
Lead developer
Syngenta
Modality
Small Molecules
Administration
Topical
01

Overview

Azoxystrobin is a broad-spectrum systemic fungicide belonging to the class of methoxyacrylates, derived from naturally-occurring strobilurins. It was first marketed in 1996 and is widely used in agriculture to protect crops from fungal diseases such as rice blast, rusts, downy mildew, powdery mildew, late blight, apple scab, and Septoria. Azoxystrobin acts by inhibiting mitochondrial respiration in fungi; specifically, it blocks electron transport at the quinol outer binding site of the cytochrome b-c1 complex (complex III), preventing ATP production—a mechanism known as "Quinone Outside Inhibitor" (QoI). The compound is xylem-mobile with translaminar activity and provides both protectant and curative properties for up to four to six weeks on cereal crops. It has low acute and chronic toxicity for humans but can be highly toxic to aquatic organisms. Azoxystrobin is formulated for use in water-based sprays and marketed under several trade names primarily by Syngenta[1][2][5][6].

Brand names
AmistarAboundPrioriQuadrisDynastyHeritage
02

Targets

CYTB (Plasmodium falciparum cytochrome bc1 complex (qi site))

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