aztreonam

Aztreonam is a synthetic monocyclic beta-lactam antibiotic belonging to the monobactam class. It was originally isolated from Chromobacterium violaceum and is structurally distinct from other beta-lactams such as penicillins and cephalosporins. Aztreonam exhibits potent bactericidal activity against a wide range of aerobic gram-negative bacteria, including Pseudomonas aeruginosa, but has little or no activity against gram-positive bacteria or anaerobes. Its mechanism of action involves binding with high affinity to penicillin-binding protein 3 (PBP3) in susceptible bacteria, thereby inhibiting the final stage of bacterial cell wall synthesis and leading to cell lysis. Aztreonam is highly resistant to many beta-lactamases produced by gram-negative organisms, making it effective even against some multidrug-resistant strains. It is used primarily for severe infections such as those involving the respiratory tract (including pneumonia), urinary tract, blood (bacteremia/sepsis), skin and soft tissue, intra-abdominal area, gynecological sites, bone infections, peritonitis, pelvic inflammatory disease, and for lung infections in cystic fibrosis patients via inhalation[1][2][5][6][9].

Brand names

AzactamCayston

Other names

aztreonam for inhalation solutionaztreonam lysine for inhalation