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Azymes
- Development stage
- Preclinical
- Lead developer
- Avivo Biomedical
- Modality
- Recombinant Proteins and Enzymes
- Administration
- Parenteral
01
Overview
Azymes is an enzymatic combination consisting of two recombinant enzymes derived from the human gut bacterium *Flavonifractor plautii*: FpGalNAc deacetylase (EnzAO1) and FpGalactosaminidase (EnzAO2). This enzyme system is designed to convert blood group A (ABO-A) red blood cells and donor organs (such as lungs, kidneys, and hearts) to the universal blood group O (ABO-O) by removing the terminal A-antigen (N-acetylgalactosamine) from cell surfaces. FpGalNAc deacetylase first deacetylates the terminal N-acetylgalactosamine of the A-antigen to a galactosamine intermediate, which is then cleaved and removed by FpGalactosaminidase, leaving the H-antigen characteristic of O-type blood. This donor-centric desensitization technology is being developed to enable ABO-incompatible organ transplantation and expand the universal donor pool, thereby reducing waitlist times and mortality.
- Other names
- Azyme enzyme systemFpGalNAc deacetylase + FpGalactosaminidaseFpGalNAcDeAc + FpGalNase
02
Targets
A antigen (Blood group A antigen)
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