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B-019
- Development stage
- Unknown
- Lead developer
- SPH Biotherapeutics
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, Gene Therapies
- Administration
- Intravenous
01
Overview
B-019 is an autologous bispecific chimeric antigen receptor T cell (CAR-T) therapy developed by SPH Biotherapeutics. It is engineered to target B-cell malignancies by expressing CARs directed against both CD19 and CD22, which are surface antigens commonly expressed on malignant B cells. The dual targeting aims to overcome antigen-loss relapse associated with single-antigen CAR-T therapies. The drug is in early-stage clinical development for hematological cancers such as B-cell leukemia and B-cell lymphoma.
- Other names
- Anti-CD19 anti-CD20 bispecific chimeric antigen receptor T cell therapyAnti-CD-19 anti-CD20 bispecific chimeric antigen receptor T cell therapyAnti-CD 19 anti-CD20 bispecific chimeric antigen receptor T cell therapyChimeric Antigen Receptor T cell targeting CD19 and CD22
02
Targets
CD19 (B lymphocyte antigen CD19)CD22 (Cluster of Differentiation 22)
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