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B7-H3 bispecific killer engager
- Development stage
- Preclinical
- Lead developer
- Sanofi
- Modality
- T-cell Engagers → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Antibody Fragments → Engineered Antibody Formats → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
B7-H3 bispecific killer engager is a **preclinical class of NK-cell engaging biologic immunotherapies** rather than a single uniquely defined drug product. These agents are typically engineered as **bispecific antibody fragment-based proteins** that bind **B7-H3** on tumor cells and **CD16** on natural killer cells, thereby promoting immune synapse formation, NK-cell activation, antibody-dependent cellular cytotoxicity-like killing, and cytokine release against B7-H3 expressing malignancies. Reported examples include a **B7-H3/CD16 BiKE** derived from the anti-B7-H3 antibody omburtamab and related research-stage constructs evaluated mainly in solid tumors such as **non-small cell lung cancer**; however, the queried term does not identify one proprietary clinical-stage asset, approved medicine, or single manufacturer.
- Other names
- B7-H3 BiKEB-7-H3 BiKEB 7-H3 BiKEB7-H3/CD16 BiKE
02
Targets
B7-H3CD3 (T-cell surface glycoprotein CD3)FCGR3A (Low affinity immunoglobulin gamma Fc region receptor III-A)
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