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B7-H4 monoclonal antibody
- Development stage
- Preclinical
- Lead developer
- Huashan Hospital
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
B7-H4 monoclonal antibody refers to a class of immunotherapeutic agents designed to target B7-H4 (also known as VTCN1), a member of the B7 family of costimulatory proteins. B7-H4 is frequently overexpressed in various malignant tumors, including glioma, breast, and ovarian cancers, where it acts as a negative regulator of T-cell-mediated immunity. By binding to B7-H4, these antibodies aim to block its inhibitory signal, thereby reversing CD8+ T-cell exhaustion and enhancing the anti-tumor immune response. Research conducted at Huashan Hospital, Fudan University, involves the translational study of B7-H4 mechanisms and the screening of monoclonal antibodies for potential use in treating a wide range of solid tumors.
- Other names
- anti-B7-H4 antibodyanti-B-7-H4 antibodyanti-B 7-H4 antibodyVTCN1 monoclonal antibodyVTCN-1 monoclonal antibodyVTCN 1 monoclonal antibody
02
Targets
VTCN1 (V-set domain containing T cell activation inhibitor 1)FcγRIIIa (Low affinity immunoglobulin gamma Fc region receptor III-A)
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