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BA2168

Development stage: Preclinical
Lead developer: T-Cypher Bio
Modality: Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, T-cell Engagers → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics
Administration: Intravenous

Overview

BA2168 is a bispecific T cell engager (TCE) currently in lead optimization by T-Cypher Bio for the treatment of various solid tumors. The molecule is designed to simultaneously bind to the tumor-associated antigen TC168 and the CD3 receptor on T cells, thereby recruiting and activating T cells to specifically eliminate TC168-expressing cancer cells. Its development targets a broad range of indications, including microsatellite stable colorectal cancer (MSS CRC), gastric, esophageal, lung, bladder, and pancreatic cancers, as well as melanoma and head and neck squamous cell carcinoma (HNSCC).

Targets

CD3 (T-cell surface glycoprotein CD3)

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