Bac-ELP-H1

Bac-ELP-H1 is a chimeric polypeptide designed to target and inhibit the c-Myc oncogene, particularly for the treatment of glioblastoma multiforme (GBM). It consists of three functional domains: a cell-penetrating peptide (CPP) derived from the antimicrobial peptide bactenecin (Bac) to facilitate cellular uptake; a thermally responsive elastin-like polypeptide (ELP) that allows for potential thermal targeting and improved pharmacokinetics; and a c-Myc inhibitory peptide (H1) that competitively blocks the interaction between c-Myc and its partner protein Max. By preventing this dimerization, Bac-ELP-H1 inhibits c-Myc-mediated transcriptional activation, leading to cell cycle arrest and reduced tumor proliferation. Preclinical studies in rat glioma models have demonstrated its ability to accumulate in brain tumors and induce tumor regression or growth delay.

Other names

Bac-ELP-c-Myc inhibitory polypeptide