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bacillus amyloliquefaciens
- Development stage
- Unknown
- Lead developer
- Bayer
- Modality
- Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics
- Administration
- Oral, Topical, Soil Application
01
Overview
*Bacillus amyloliquefaciens* is a Gram-positive, aerobic, spore-forming bacterium widely utilized as a biocontrol agent in agriculture and a probiotic in animal nutrition and human health. It belongs to the *Bacillus subtilis* species complex and is characterized by its robust ability to colonize the rhizosphere and gastrointestinal tract. Its primary mechanism of action involves the synthesis of a diverse array of secondary metabolites, including cyclic lipopeptides (surfactin, iturin, and fengycin) and polyketides (difficidin, macrolactin), which exhibit potent antifungal and antibacterial activities. In plants, it triggers induced systemic resistance (ISR) by activating jasmonic acid and ethylene signaling pathways. In animals, specific strains enhance intestinal barrier function, modulate immune responses, and alleviate oxidative stress. Additionally, it is a significant industrial source of enzymes such as alpha-amylase and proteases, and is employed in the biodegradation of mycotoxins like aflatoxin B1 and zearalenone.
- Brand names
- SerenadeDouble Nickel 55TaegroEcobiolDisease Pro Ba
- Other names
- B. amyloliquefaciensBacillus amyloliquefaciens plantarum
02
Targets
PGN (Peptidoglycan)Sucrase-IsomaltaseWT1 (Wilms tumor protein)
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