Drug intelligence / Profile preview

bacillus clausii + oral rehydration therapy

Development stage
Unknown
Lead developer
Sanofi
Modality
Live Biotherapeutic Products → Microbiome Therapeutics
Administration
Oral
01

Overview

Bacillus clausii combined with oral rehydration therapy (ORT) is a therapeutic approach utilized for the management of acute diarrhea, primarily in infants and children. Bacillus clausii is a spore-forming, polyantibiotic-resistant probiotic bacterium that promotes the restoration of the intestinal microflora balance, while oral rehydration therapy replenishes essential fluids and electrolytes to prevent or treat dehydration. This combination approach, frequently administered alongside zinc supplementation as part of standard pediatric care, has been evaluated in Phase 3 clinical trials to determine its clinical efficacy in reducing the duration and severity of diarrheal episodes compared to standard rehydration alone.

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