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Bacillus subtilis spore extract

Development stage: Unknown
Lead developer: DreamTec
Modality: Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Vaccines & Immunotherapeutics
Administration: Oral

Overview

Bacillus subtilis spore extract is a genetically engineered product utilizing Bacillus subtilis, a harmless intestinal commensal, as a vaccine production host and delivery vector. This extract is designed to carry the Spike protein of the SARS-CoV-2 virus on its spore coat. The product aims to stimulate an immune response within the intestinal environment, thereby exhibiting vaccine-like activity. It is being investigated as an oral neutralizing antibody booster for individuals who have received a COVID-19 vaccine.

Targets

SARS-CoV-2 spike

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