Drug intelligence / Profile preview

bacitracin + polymyxin B + nystatin

Development stage
Unknown
Modality
Small Molecules
Administration
Topical
01

Overview

A combination antimicrobial preparation containing bacitracin, polymyxin B, and nystatin. This topical formulation provides broad-spectrum coverage against both bacterial and fungal infections. * **Bacitracin** inhibits bacterial cell wall synthesis. * **Polymyxin B** disrupts the outer cell membrane of Gram-negative bacteria by displacing calcium and magnesium ions from phosphates of membrane lipids, increasing membrane permeability and causing cytoplasmic leakage. * **Nystatin** is an antifungal agent that targets fungal infections, particularly those caused by Candida species. This combination is often used in compounded preparations for burn care and other skin infections.

02

Targets

UppP (Undecaprenyl-diphosphate phosphatase)ErgosterolLipid A

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