baclofen + buprenorphine

Baclofen + buprenorphine is a combination therapy being investigated by the University of Alabama at Birmingham for the management of acute pain. Baclofen is a small molecule GABA-B receptor agonist traditionally used as a skeletal muscle relaxant, while buprenorphine is a small molecule partial mu-opioid receptor agonist and kappa-opioid receptor antagonist used for analgesia and the treatment of opioid use disorder. The combination aims to leverage baclofen's potential as an analgesic adjuvant to synergistically enhance the pain-relieving effects of buprenorphine. This approach is being studied to determine if effective analgesia can be achieved with lower opioid doses, potentially reducing the risk of opioid-related side effects and misuse.

Other names

baclofen and buprenorphine combinationbuprenorphine + baclofen