Drug intelligence / Profile preview

bacterial spray-University Ghent-bromhidrosis

Development stage: Unknown
Lead developer: Ghent University
Modality: Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration: Topical

Overview

The bacterial spray developed at Ghent University is an investigational live biotherapeutic product for the treatment of bromhidrosis, also known as axillary malodor or persistent underarm odor. [7, 16] Developed by a research team led by Dr. Chris Callewaert, the therapy is administered as a topical spray. [2, 6, 7] Its mechanism of action involves microbiome transplantation, where the spray delivers a community of 'good', non-odor-causing bacteria (such as *Staphylococcus* species) to the underarm skin. [2, 7] This is intended to displace the endogenous, malodor-producing bacteria (primarily *Corynebacterium* species) and establish a healthier, non-smelling skin microbiome. [2, 5, 10] A Phase 2 clinical trial (NCT03967470), titled "Bacteriotherapy to Improve Underarm Odor," has been completed to evaluate the efficacy of this approach. [8, 9]

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