Drug intelligence / Profile preview

bacteriophage-based gel

Development stage
Unknown
Lead developer
MicroMir
Modality
Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Small Molecules
Administration
Intravesical, Topical
01

Overview

Bacteriophage-based gel (also known as the complex antibacterial and anesthetic/analgesic bacteriophage gel) is an investigational topical and intraurethral formulation developed by the Yevdokimov Moscow State University of Medicine and Dentistry in collaboration with RPC MicroMir. The gel is designed to prevent urinary tract infections (UTIs), including catheter-associated urinary tract infections (CAUTIs), and provide local anesthesia during diagnostic and therapeutic urological procedures (such as cystoscopy and catheterization). It consists of a cocktail of multiple virulent bacteriophages targeting common uropathogens (such as Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Proteus mirabilis) co-formulated with the local anesthetic lidocaine hydrochloride and the antiseptic chlorhexidine hydrochloride in a water-soluble gel base. Clinical studies have demonstrated its efficacy in reducing bacteriuria and post-procedural pain compared to standard chlorhexidine-lidocaine gels.

Other names
antibacterial and analgesic drug based on bacteriophages in gel formantibacterial and anesthetic drug based on bacteriophages in gel formbacteriophages-based complex antibacterial and analgesic drug in gel formulationcomplex antibacterial and analgesic drug based on bacteriophages in gel formcomplex antibacterial and anesthetic drug based on bacteriophages in gel form
02

Targets

NaV (Voltage-gated sodium channels)

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