Drug intelligence / Profile preview

bacteriophage MSP16

Development stage
Preclinical
Lead developer
Centro Universitário São Camilo
Modality
Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics
Administration
Topical
01

Overview

Bacteriophage MSP16 is a temperate bacteriophage belonging to the genus *Fibralongavirus* within the *Siphoviridae* family [P2690]. It was isolated from canine skin swabs and veterinary clinic wastewater in Brazil [P2690]. MSP16 exhibits broad-spectrum lytic activity against methicillin-resistant *Staphylococcus pseudintermedius* (MRSP) strains, which are major causes of canine skin and wound infections [P2690]. The phage genome encodes a holin-endolysin lysis system and anti-CRISPR (Acr) proteins that facilitate evasion of bacterial defense mechanisms [P2690]. MSP16 is under preclinical development for the treatment and management of MRSP infections in companion dogs, demonstrating both biofilm prevention and degradation capabilities [P2690].

Other names
Staphylococcus phage MSP16phage MSP16

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