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bacteroides fragilis BF839 + lumbrokinase

Development stage
Preclinical
Modality
Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Therapeutic Enzymes → Recombinant Proteins and Enzymes
Administration
Oral
01

Overview

This is a combination product consisting of two active components: - **Bacteroides fragilis BF839** is a specific probiotic strain of the gut bacterium Bacteroides fragilis. It has been studied for its potential to modulate the gut microbiome and exert beneficial effects in neurological and metabolic diseases. Clinical research indicates that oral administration of Bacteroides fragilis BF839 can improve symptoms in conditions such as refractory epilepsy and Parkinson’s disease by influencing gut-brain axis signaling[1][4][5]. It has also been investigated for use in obesity and diabetes management due to its impact on metabolic pathways[2][3]. - **Lumbrokinase** (地龙蛋白) is an enzyme complex derived from earthworms (Eisenia fetida), known for its fibrinolytic (clot-dissolving) activity. Lumbrokinase is used primarily as a dietary supplement or adjunct therapy to support cardiovascular health by promoting blood circulation and reducing thrombosis risk. The combination aims to leverage both the neuroprotective/metabolic regulatory effects of Bacteroides fragilis BF839 and the circulatory benefits of lumbrokinase. Recent clinical studies suggest this combination may significantly improve motor symptoms, non-motor symptoms (such as anxiety, depression, constipation) in Parkinson’s disease patients[1], with ongoing research into other indications.

Other names
脆弱拟杆菌BF839 + 地龙蛋白
02

Targets

CDH1 (Cadherin-1)Fibrin (Factor Ia)

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