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Bacteroides thetaiotaomicron
- Development stage
- Unknown
- Lead developer
- 4D pharma
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
Thetanix is the brand name for a single-strain, live biotherapeutic product (LBP) containing the bacterium *Bacteroides thetaiotaomicron*. [1, 5] It was developed by 4D Pharma for the treatment of Crohn's disease, particularly in pediatric and adolescent populations. [2, 4] As an LBP, its mechanism of action involves modulating the host's gut microbiome. Preclinical and clinical studies suggest it may reduce inflammation by antagonizing the NF-κB transcription factor, which in turn reduces pro-inflammatory cytokines like TNF-α. [1, 2, 5] Thetanix is administered as an oral, gastroresistant capsule. [2, 3] A Phase 1b clinical trial in adolescents with stable Crohn's disease found the treatment to be safe and well-tolerated. [1, 6]
- Brand names
- Thetanix
02
Targets
PPARG (Peroxisome proliferator-activated receptor gamma)
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