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bacTRL nAB
- Development stage
- Preclinical
- Lead developer
- Symvivo
- Modality
- Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Gene Therapies
- Administration
- Oral, Intravenous
01
Overview
bacTRL nAB is a preclinical gene therapy candidate developed by Symvivo for the treatment or prevention of COVID-19. It utilizes Symvivo's proprietary **bacTRL™** platform, which employs engineered *Bifidobacterium longum* (a probiotic bacterium) as a vector to deliver plasmid DNA directly to the patient's cells, typically via oral or intravenous administration. In this specific application, the plasmid is designed to encode neutralizing antibodies (nAbs) against the SARS-CoV-2 virus. Once the DNA is internalized by the host's cells, the cells' own machinery produces and secretes the therapeutic antibodies *in vivo*. This approach aims to provide a scalable and potentially long-lasting alternative to traditional monoclonal antibody infusions by turning the patient's own body into a factory for the therapeutic protein.
- Other names
- bacTRL neutralizing antibodybacTRL-nAB
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