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BAHCS1
- Development stage
- Preclinical
- Lead developer
- U.S. Food & Drug Administration
- Modality
- Vaccines & Immunotherapeutics, Recombinant Proteins and Enzymes
- Administration
- Subcutaneous
01
Overview
BAHCS1 (Babesia alpha-helical cell surface 1, also known as BmSA1) is a GPI-anchored protein expressed on the surface of *Babesia microti* merozoites and in the cytoplasm of infected erythrocytes. It is being investigated as a recombinant protein subunit vaccine candidate for the prevention of human babesiosis, a tick-borne zoonosis caused by the intraerythrocytic parasite *Babesia microti*. In preclinical studies, immunization with recombinant BAHCS1 (expressed in *E. coli* or mammalian cells) formulated with adjuvants such as Montanide ISA 51/CpG has been shown to induce strong humoral and cellular immune responses, leading to a significant reduction in peak parasitemia and overall parasite burden following challenge.
- Other names
- Babesia alpha-helical cell surface 1Babesia microti alpha helical cell surface protein 1Babesia microti surface antigen 1
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