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baicalein + human umbilical cord mesenchymal stem cell-derived exosomes
- Development stage
- Preclinical
- Modality
- Small Molecules, Cell Therapies, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intperitoneal
01
Overview
Baicalein + human umbilical cord mesenchymal stem cell-derived exosomes (Exo@Bac) is an experimental nanotherapeutic combination consisting of the flavonoid baicalein encapsulated within exosomes harvested from human umbilical cord mesenchymal stem cells (hUC-MSCs). This formulation is designed to enhance the bioavailability and therapeutic efficacy of baicalein, a compound known for its antioxidant and anti-inflammatory properties, by utilizing the natural blood-brain barrier-crossing capabilities and intrinsic regenerative potential of MSC-derived exosomes. Preclinical studies in Alzheimer's disease models indicate that Exo@Bac mitigates neurodegeneration by activating the AMPK pathway and inhibiting NF-κB signaling, leading to reduced amyloid-beta deposition, decreased pro-inflammatory cytokine production (TNF-α, IL-6, IL-1β), and enhanced antioxidant defense (SOD). This dual-action approach addresses multiple pathological hallmarks of Alzheimer's, including oxidative stress and neuroinflammation.
- Other names
- Baicalein-encapsulated hUC-MSC exosomesBaicalein-loaded human umbilical cord mesenchymal stem cell-derived exosomeshUC-MSC@Exo-Bac
02
Targets
SIRT1 (NAD-dependent protein deacetylase sirtuin-1)MAPK3 (Mitogen-activated protein kinase 1)TLR4 (Toll-like receptor 4)
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