Drug intelligence / Profile preview

baitouweng

Development stage
Unknown
Administration
Oral, Rectal Enema, Transendoscopic Enteral Tubing
01

Overview

Baitouweng refers primarily to the dried root of Pulsatilla chinensis, a herb widely used in Traditional Chinese Medicine (TCM) for its bitter, cold properties targeting the stomach, liver, and large intestine meridians[1][8]. In medicinal formulas, baitouweng is used to clear heat and toxins, particularly for intestinal disorders like dysentery, diarrhea, ulcerative colitis, and intestinal infections[1][8]. It possesses anti-inflammatory, antimicrobial, analgesic, and hemostatic effects, and research suggests it can also promote intestinal mucosal healing and modulate inflammatory cytokines[2][3][4]. The principal modern clinical application is as the lead ingredient in the classical formula Baitouweng decoction, which has demonstrated symptom improvement and better safety profiles versus some Western medicines in ulcerative colitis, partly by modulating tryptophan metabolism, regulating inflammatory cytokines, and enhancing the intestinal barrier through pathways such as AHR/IL-22[2][3][4]. The main active constituent is anemonin, a powerful irritant at high doses found in the root[8].

Other names
Bai Tou WengPulsatilla chinensisChinese anemone rootPulsatilla decoctionBai-Tou-Weng-Tang
02

Targets

AHR (Aryl hydrocarbon receptor)DDC (Aromatic L-amino acid decarboxylase)IL1B (Interleukin-1 beta)IL10 (Interleukin-10)IL22 (Interleukin 22)IL-6 (Interleukin 6)IL8 (C-X-C Motif Chemokine Ligand 8)TNFA (Tumor necrosis factor alpha (soluble))

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