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Baked egg refers to chicken egg that has been extensively heated (typically in baked goods such as muffins or cakes) and is used as a form of oral immunotherapy (OIT) for individuals with IgE-mediated hen's egg allergy. The heating process alters the structure and allergenicity of certain proteins in the egg, particularly reducing the allergenicity of ovalbumin and ovotransferrin while ovomucoid remains relatively heat-stable. In clinical protocols, patients consume measured amounts of baked egg daily or several times per week to induce tolerance or desensitization to hen's eggs. Baked egg therapy is distinct from traditional OIT using raw or pasteurized dried egg white powder; it is generally considered safer but may be less effective at inducing sustained unresponsiveness compared to standard OIT. Most adverse reactions are mild and manageable with antihistamines; severe reactions are rare[2][6][8][10].
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