bakuchiol + ethyl linoleate

Bakuchiol + ethyl linoleate is a topical combination of two natural ingredients, bakuchiol (a plant-derived functional analog of retinol) and ethyl linoleate (a fatty acid ester), developed for skincare applications. This combination exerts synergistic effects in keratinocytes by **inhibiting fatty acid binding protein 5 (FABP5)** and **fatty acid amide hydrolase (FAAH)**, resulting in increased levels of endocannabinoid (eCB) ligands (such as AEA, 2-AG, OEA, and PEA). This leads to enhanced activation of cannabinoid receptors (CB1, CB2) and TRPV1, with downstream suppression of inflammatory pathways (reduction of TNF, COX-2, type I interferon gene expression), reversal of TNF-induced gene shifts, and inhibition of cortisol secretion. Bakuchiol + ethyl linoleate also upregulates genes linked to cell proliferation and stemness while repressing those for keratinocyte differentiation. The formulation is primarily intended as an **innovative topical agent for managing inflammatory and compromised skin conditions** such as acne and atopic dermatitis. It is marketed by Sytheon under the brand name Asyntra D-Stress[1][2][4][5].

Brand names

Asyntra D-Stress

Other names

bakuchiol + ELNbakuchiol + ethyl (linoleate/oleate)