Drug intelligence / Profile preview

Bakutrol A

Development stage
Unknown
Lead developer
Unigen
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Topical
01

Overview

Bakutrol A is a proprietary botanical cosmeceutical ingredient developed by Unigen, Inc., primarily for use in cosmetic and personal care products targeting acne and skin blemishes. It is a hydrolyzed extract derived from the seeds of *Psoralea corylifolia*, enriched to contain at least 60% bakuchiol. The ingredient functions as a multi-targeted agent with antimicrobial activity against acne-causing bacteria, inhibition of inflammatory enzymes including cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), and 5-lipoxygenase (5-LOX), and potent antioxidant properties. Clinical studies have shown its effectiveness in reducing both inflammatory and non-inflammatory acne lesions and post-inflammatory hyperpigmentation without the irritation typically associated with synthetic treatments like benzoyl peroxide.

Brand names
Bakutrol ABakutrol
Other names
bakuchiol
02

Targets

ALOX5 (Arachidonate 5-lipoxygenase)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)PGHS-1 (Prostaglandin G/H Synthase 1)

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