BAM8-22

BAM8–22 is a 15-amino acid endogenous peptide fragment derived from proenkephalin A. It acts as a potent and selective agonist for Mas-related G protein-coupled receptors (MRGPRs), specifically human MRGPRX1 and mouse MrgprC11. Unlike related peptides containing the met-enkephalin motif, BAM8–22 does not bind opioid receptors. In preclinical models, it induces scratching behavior in mice via activation of sensory neuron-specific GPCRs and is considered an endogenous pruritogen mediating histamine-independent itch in both mice and humans. Additionally, it has been shown to attenuate bone cancer pain in animal models by modulating mitochondrial function in spinal cord neurons[1][4][5][6][7][10].

Other names

BAM (8-22) acetateBovine adrenal medulla peptide (8-22)L-Valyl-glycyl-L-arginyl-L-prolyl-L-glutamyl-L-tryptophyl-L-tryptophyl-L-methionyl-L-aspartyl-L-tyrosyl-L-glutaminyl-L-lysyl-L-arginyl-L-tyrosyl-glycineVal-Gly-Arg-Pro-Glu-Trp-Trp-Met-Asp-Tyr-Gln-Lys-Arg-Tyr-Gly