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bamboo salt + magnolia bark extract + centella asiatica extract

Development stage
Phase 3
Lead developer
Seoul National University
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Topical
01

Overview

This experimental mouthrinse formulation, developed by researchers at Seoul National University, is a combination of three natural active ingredients: bamboo salt, magnolia bark extract, and *Centella asiatica* extract. Bamboo salt is a traditional Korean remedy produced by roasting sea salt in bamboo, known for its anti-inflammatory and antiseptic properties. Magnolia bark extract contains bioactive biphenols, such as honokiol and magnolol, which exhibit potent antimicrobial activity against oral pathogens. *Centella asiatica* extract is included for its well-documented wound-healing and anti-inflammatory effects, which aid in gingival tissue repair. The formulation was evaluated in a randomized crossover clinical trial to compare the efficacy of aqueous single-phase (ASM) and oil-water two-phase (OTM) versions in reducing gingivitis and dental plaque. Results indicated that the aqueous formulation significantly reduced bleeding on probing, suggesting clinical utility in managing periodontal inflammation.

Other names
bamboo salt, magnolia bark and centella asiatica mouthrinse

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