Drug intelligence / Profile preview

Banxia Xiexin Decoction

Development stage
Phase 3
Lead developer
Sanwa Shoyaku
Administration
Oral
01

Overview

Banxia Xiexin Decoction is a classical traditional Chinese medicine (TCM) herbal formula first recorded in the 2nd century in the text *Shanghan Lun*. It consists of seven herbs including Pinellia (Ban Xia), Scutellaria (Huang Qin), Coptis (Huang Lian), dried ginger (Gan Jiang), jujube (Da Zao), Codonopsis (Dang Shen), and licorice root (Zhi Gan Cao). The formula is designed to harmonize stomach and intestinal function by clearing stomach heat and warming intestinal cold, drying spleen dampness, restoring digestive qi flow, and addressing symptoms such as epigastric fullness, discomfort, restlessness, or insomnia. It is traditionally used for gastrointestinal inflammatory syndromes including chronic atrophic gastritis, ulcerative colitis, gastroesophageal reflux disease, and Helicobacter pylori infection. Recent studies suggest it modulates gut microbiota composition and metabolism related to amino acids, purines, and lipids which may underlie its therapeutic effects[2][3][4][5][6].

Brand names
Hange-shashin-to
Other names
Banxia Xiexin TangPinellia Decoction for Draining the Heart
02

Targets

STAT3 (Signal Transducer and Activator of Transcription 3)VEGFA (Vascular endothelial growth factor A)GR (Glucocorticoid receptor)NOS2 (Nitric Oxide Synthase 2)EGFR T790M (Epidermal growth factor receptor T790M mutant)IL-6 (Interleukin 6)IL-2 (Interleukin 2)

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