Drug intelligence / Profile preview

bapta-am

Development stage: Preclinical
Modality: Small Molecules
Administration: In Vitro (cell Culture), In Vivo (animal Experimentation, E.g. Intraperitoneal, Intravenous)[3]

Overview

BAPTA-AM is a **cell-permeable, synthetic small molecule calcium chelator** used primarily in research settings to manipulate intracellular calcium (Ca^2+) levels[2][3][5]. It is an acetoxymethyl (AM) ester derivative of BAPTA, enabling passive diffusion across cell membranes[2][5][7]. Once inside the cell, cytosolic esterases cleave the AM esters, releasing BAPTA which tightly chelates Ca^2+, allowing experimental control of intracellular Ca^2+ activity[2][5][7]. BAPTA-AM is used to control Ca^2+-dependent processes in cell signaling, block voltage-gated and Ca^2+-activated potassium channels (Kv1.5, hERG/Kv11.1, Kv1.3), inhibit apoptosis, study synaptic plasticity, or investigate Ca^2+-regulated biological pathways and diseases (e.g., neurodegeneration, cancer models)[2][3][5][6][9].

Other names: acetyloxymethyl 2-[N-[2-(acetyloxymethoxy)-2-oxoethyl]-2-[2-[2-[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]phenoxy]ethoxy]anilino]acetate1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid tetrakis(acetoxymethyl ester)CB0461324CB-0461324CB 0461324126150-97-8

Targets

KCNH2 (Voltage-gated potassium channel subfamily H member 2)KCNA1 (Voltage-gated potassium channel subfamily A member 1)KCNA5 (Ultra-rapid delayed rectifier potassium channel)KCNA3 (Potassium voltage-gated channel subfamily A member 3)

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