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basifungin
- Development stage
- Discontinued
- Lead developer
- Takara Shuzo
- Modality
- Antimicrobial Peptides → Native Peptides → Peptides, Cyclic Peptides → Modified Peptides → Peptides, Small Molecules
- Administration
- Oral
01
Overview
Basifungin, also known as aureobasidin A, is an orally available cyclic depsipeptide antifungal antibiotic produced by the fungus Aureobasidium pullulans. It acts as a potent inhibitor of inositol phosphorylceramide synthase (IPC synthase), an enzyme essential for fungal sphingolipid biosynthesis. By inhibiting this enzyme, basifungin disrupts fungal cell membrane formation and growth, leading to fungicidal activity at low concentrations. Basifungin demonstrated strong activity against various pathogenic fungi including Candida species and Aspergillus species. The drug was developed by Takara Shuzo (Takara Holdings), Eli Lilly and Company, and Nippon Kayaku for the treatment of mycoses (fungal infections). However, its development was discontinued before approval[1][3][4][5][6].
- Other names
- aureobasidin AAbAbreomycin A
02
Targets
IPC synthase (Inositol phosphorylceramide synthase)
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