Drug intelligence / Profile preview

basil extract

Development stage
Phase 2
Lead developer
Mahidol University
Administration
Oral, Topical
01

Overview

Basil extract is a botanical substance derived from various species of the *Ocimum* genus, most notably *Ocimum basilicum* (sweet basil) and *Ocimum sanctum* (holy basil or tulsi). The extract is rich in bioactive polyphenols, including rosmarinic acid, luteolin, and various flavonoids, which confer antioxidant, anti-inflammatory, and antimicrobial properties. In clinical research, basil extract is being evaluated for its ability to reduce gastric mucosal inflammation in functional dyspepsia and to manage recurrent aphthous stomatitis through topical application. Preclinical studies also suggest potential therapeutic roles in managing hyperglycemia, hyperlipidemia, and bacterial pneumonia by modulating pro-inflammatory cytokines and oxidative stress pathways. Beyond its medicinal applications, it is utilized as a natural preservative in food systems and as an immunostimulant in aquaculture.

Brand names
Zetalife
Other names
Ocimum sanctum extractOcimum basilicum extractTulsi extractHoly basil extractSweet basil extractPurple basil extract
02

Targets

Sucrase-IsomaltaseALOX5 (Arachidonate 5-lipoxygenase)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)NOS2 (Nitric Oxide Synthase 2)IL-6 (Interleukin 6)AMY (Pancreatic alpha-amylase)PNLIP (Pancreatic triacylglycerol lipase)TNFA (Tumor necrosis factor alpha (soluble))AcetylcholinesteraseMMP12 (Macrophage Metalloelastase)NF-κB

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