BAY 11-7082

BAY 11-7082 is a synthetic, cell-permeable small molecule primarily known as an irreversible inhibitor of the **NF-κB pathway** and the **NLRP3 inflammasome**. It inhibits phosphorylation of IκB-α by interfering with IκB kinase activity, thereby preventing NF-κB translocation to the nucleus and subsequent transcriptional activation of pro-inflammatory genes[1][4][7]. BAY 11-7082 also directly inhibits the ATPase activity of NLRP3, blocking inflammasome activation, and functions as an active site-directed irreversible inhibitor of protein tyrosine phosphatases (PTPs)[1][4][7]. Additional described activities include blocking IRF3, STAT1, ERK, p38, and JAK2 signaling[1]. Research suggests potential utility for **anti-inflammatory**, **anti-cancer**, and **neuroprotective** purposes in preclinical models, including mouse models of autoimmune encephalomyelitis and various cancer lines[1][3][6]. BAY 11-7082 is not approved for clinical use and is primarily used as a research tool compound[6].

Brand names

BAY 11-7082BAY11-7082BAY-11-7082

Other names

BAY 11-7082BAY11-7082BAY-11-708219542-67-7