bay k 8644

**BAY K 8644** is a synthetic small molecule, structurally related to dihydropyridine calcium channel blockers, and functions as an **L-type voltage-gated calcium channel agonist** (specifically, an activator), though it can also exert antagonist/blocking properties in a use- and voltage-dependent manner. It is widely used as a biochemical and pharmacological tool to study the physiology and pharmacology of calcium currents, especially in cardiac and neuronal cells. BAY K 8644 has positive inotropic and vasoconstrictive effects in animal models and can modulate hormone secretion by enhancing calcium-dependent exocytosis. Its behavioral and in vivo cardiovascular effects are dose- and enantiomer-dependent[2][3][4][5][6][7].

Other names

methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate(+/-)-BAY K 8644Bay K8644