BAY11-7085

BAY11-7085 is an experimental **small-molecule NF-\u03baB pathway inhibitor** widely used as a research tool rather than a marketed therapeutic drug. It was originally characterized as an inhibitor of cytokine-induced I\u03baB\u03b1 phosphorylation, thereby suppressing activation of the NF-\u03baB transcriptional program; subsequent literature also describes covalent, electrophile-like reactivity and activity against additional proteins, including inflammasome-related signaling and bacterial thioredoxin reductase in mechanistic studies. In the biomedical literature provided here, BAY11-7085 is consistently used to block NF-\u03baB-dependent inflammatory signaling across cell and animal models, including retinal inflammation and angiogenesis, microglial activation, fibrosis-associated signaling, cancer resistance pathways, and macrophage polarization. It does not appear to be an approved medicine, and there is no clear evidence from the provided context that it has advanced as a clinical-development asset for a defined indication.

Other names

BAY11-7085BAY-11-7085BAY 11-7085