Drug intelligence / Profile preview

BCA356

Development stage: Preclinical
Lead developer: Bicara Therapeutics
Modality: Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes, Cytokines & Interferons → Recombinant Proteins and Enzymes

Overview

**BCA356** is a preclinical, tumor-targeted immunocytokine developed by Bicara for CAIX-expressing solid tumors, notably clear cell renal cell carcinoma. It is a bispecific humanized IgG1-based fusion molecule that binds carbonic anhydrase IX and carries an attenuated interleukin-12 payload fused to its heavy chains in a knob-in-hole format. The design is intended to localize IL-12 activity to the tumor microenvironment, activate innate and adaptive antitumor immunity, retain antibody-dependent cellular cytotoxicity activity, and reduce the systemic toxicity associated with unconjugated IL-12.

Targets

CA9 (Carbonic anhydrase IX)IL-12R (Interleukin-12 receptor)

Beyond the preview

Go deeper on BCA356.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Follow clinical development from study design and recruitment through results.

Trial phase
Status
Readouts

Indications & development

Explore development by indication, patient population, and geography.

Indications
Development status
Countries

Licensing & deals

Trace asset ownership, licensing agreements, and commercial partnerships.

Partners
Deal terms
Milestones

Patents & exclusivity

Explore the patent landscape and regulatory exclusivity around an asset.

Patents
Expiration dates
Exclusivity

Competitive landscape

Compare development programs by target, modality, and indication.

Competing assets
Targets
Development stage

Research & analysis

Connect source evidence and development news to your research questions.

Publications
News
Analysis

Bring the full picture into focus.

See how Gosset can support your research on BCA356.

Explore the full profile