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BCD-020 + methotrexate
- Development stage
- Unknown
- Lead developer
- Biocad
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous, Oral, Subcutaneous
01
Overview
Combination of **BCD-020**, a biosimilar of rituximab (a chimeric anti-CD20 monoclonal antibody targeting CD20 on B lymphocytes), and **methotrexate**, a folate antagonist antimetabolite with anti-inflammatory and antineoplastic activity. This combination is investigated for the treatment of conditions such as rheumatoid arthritis, leveraging BCD-020 for B cell depletion and methotrexate as an immunosuppressant and disease-modifying anti-rheumatic drug. BCD-020 is developed to be highly similar to originator rituximab in pharmacokinetics, efficacy, safety, and immunogenicity. Methotrexate inhibits dihydrofolate reductase, disrupting nucleotide synthesis and immune cell proliferation[1][2][3][4][6][7][9].
- Other names
- rituximab biosimilar BCD-020 + methotrexate
02
Targets
CD20 (B-lymphocyte antigen CD20)DHFR (Dihydrofolate reductase)
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