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bcg + tremelimumab
- Development stage
- Discontinued
- Lead developer
- AstraZeneca
- Modality
- Vaccines & Immunotherapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravesical, Intravenous
01
Overview
BCG + tremelimumab is an investigational combination therapy consisting of the live-attenuated bacterial immunotherapy Bacillus Calmette-Guérin (BCG) and the fully human monoclonal antibody tremelimumab (formerly CP-675,206). Tremelimumab is an immune checkpoint inhibitor that targets Cytotoxic T-Lymphocyte-Associated Antigen 4 (CTLA-4), thereby enhancing T-cell activation and proliferation. BCG is a standard intravesical treatment for bladder cancer that induces a local inflammatory and immune response. This combination was evaluated in a Phase I trial (NCT00880854) by the University of Wisconsin-Madison for patients with BCG-resistant localized transitional cell carcinoma of the bladder, aiming to overcome resistance by combining local and systemic immunotherapy. The trial was ultimately withdrawn due to poor accrual.
- Other names
- BCG + CP-675,206BCG + tremelimumabBCG + ticilimumab
02
Targets
CTLA-4 (Cytotoxic t-lymphocyte–associated protein 4)
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